Opportunity Information: Apply for PA 18 687
The NIH funding opportunity titled "Developmental Pharmacodynamics and Models of Drug Effects in Pediatrics (R03 Clinical Trial Optional)" (FOA number PA-18-687) supports small, investigator-initiated research projects aimed at improving how drug effects are understood and predicted across pediatric age groups. The emphasis is on developmental pharmacodynamics, meaning how a childs changing biology and physiology across infancy, childhood, and adolescence can alter a drugs effects, including desired therapeutic responses and adverse effects. The FOA is designed to push the field beyond simply knowing what dose was given and what blood levels were achieved, and instead build stronger evidence for what those exposures actually do in children at different developmental stages.
A central goal is to generate and strengthen data that define pediatric pharmacodynamic responses and to enable clearer pharmacokinetic-pharmacodynamic (PK-PD) relationships for drugs used in children. In practice, that means projects can focus on identifying measurable biomarkers of response, characterizing exposure-response patterns, and developing or refining models that connect drug concentrations (or other exposure metrics) to clinical or biological effects. The program explicitly welcomes multidisciplinary work, which commonly involves collaboration among pediatric clinicians, clinical pharmacologists, pharmacometricians, statisticians, translational scientists, and laboratory investigators. Because the FOA is "Clinical Trial Optional," applications may include clinical trials when appropriate, but they are not required; strong mechanistic, translational, modeling, or observational approaches can also fit if they materially advance understanding of developmental drug effects.
The mechanism is an R03, which is typically intended for short, focused projects, pilot studies, feasibility work, or the collection of preliminary data that can justify a larger future study. The listed award ceiling is $50,000, reflecting the small-grant nature of the program. The funding instrument is a grant and the activity category is listed under health, income security, and social services, with CFDA number 93.865. The opportunity was created on March 1, 2018, and the original closing date shown in the source information is May 7, 2021.
Eligibility is broad and includes many types of domestic U.S. entities such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions when specified); for-profit organizations other than small businesses; and small businesses. In addition, the FOA calls out a wide range of other eligible applicants and settings, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal agencies; faith-based or community-based organizations; regional organizations; U.S. territories or possessions; and even non-domestic (non-U.S.) entities (foreign organizations), which signals an interest in broad participation where the science and pediatric relevance are strong.
Overall, this opportunity is about building the evidence base and analytic tools needed to understand and predict how drugs actually work in children as they grow, supporting better dosing decisions, safer therapy, and more reliable translation of pediatric drug responses into clinical practice.Apply for PA 18 687
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacodynamics and Models of Drug Effects in Pediatrics (R03 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2018-03-01.
- Applicants must submit their applications by 2021-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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