Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed) | RFA CA 28 013

Opportunity Information: Apply for RFA CA 28 013

The Carcinogen Hazard Assessment Monographs Program (CHAMP) is a National Cancer Institute (NCI) funding opportunity that supports rigorous, evidence-based evaluations of substances, exposures, or agents that may pose carcinogenic hazards to humans. Funded through an NIH R01 mechanism (clinical trials are not allowed), the program is designed to produce careful, systematic assessments of the existing scientific literature, with the goal of identifying and characterizing potential carcinogens. These types of hazard evaluations play a practical role in the broader cancer ecosystem because they can help set research priorities, clarify where evidence is strong or uncertain, and inform cancer prevention and control strategies by improving understanding of what exposures may contribute to cancer risk.

At its core, CHAMP is about critically reviewing and synthesizing evidence rather than running interventional studies in people. Projects are expected to take a structured, transparent approach to evaluating the full body of relevant research, which can include human epidemiology, animal bioassays, mechanistic data, and other supporting lines of evidence. The emphasis is on credibility and rigor: the work should be systematic, well-documented, and capable of withstanding scientific scrutiny, since monograph-style assessments can influence how the research community thinks about hazards and where new studies are most needed.

This opportunity is listed as a discretionary grant program administered by the National Institutes of Health (NIH), with NCI as the sponsoring institute. It falls under the health funding activity category and references CFDA (assistance listing) numbers 93.393, 93.396, and 93.399, which are commonly associated with NCI research support. The funding opportunity number is RFA-CA-28-013, and the title explicitly notes the R01 format and that clinical trials are not permitted under this announcement.

In terms of who can apply, eligibility is broad and spans many organization types. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both with and without 501(c)(3) status, excluding those that are institutions of higher education in the nonprofit category language); for-profit organizations other than small businesses; and small businesses, along with other entities that meet NIH requirements. The NOFO also contains specific rules about international participation. Non-U.S. entities (foreign organizations) are allowed to apply directly, but non-U.S. components of U.S. organizations are not eligible to apply. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed, which is an important distinction for applicants considering international collaborations or overseas subawards; the structure of the project team and where work will be performed needs to align with those restrictions.

The opportunity anticipates a very limited number of awards, with an expected total of one award. The listed award ceiling is $700,000, which indicates the maximum amount expected under the announcement (applicants should still confirm how NCI interprets this cap, such as whether it is per year or total project cost, by checking the full NOFO). The original closing date is February 9, 2027, and the posting indicates a creation date of October 9, 2026, suggesting it is a relatively recent solicitation with a defined application window.

Overall, CHAMP is aimed at supporting high-quality, monograph-style carcinogen hazard assessments that can clarify carcinogenic potential based on the existing science. The program is positioned to strengthen the foundation for cancer research and prevention by making the evidence base easier to interpret, highlighting gaps that need additional study, and helping stakeholders understand where carcinogenic hazards may exist. For full requirements, deliverables, and any topic priorities NCI may specify, applicants would need to consult the NOFO sections in detail, especially the eligibility provisions and any instructions on the expected scope and methodological standards for the hazard evaluations.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.396, 93.399.
• This funding opportunity was created on 2026-10-09.
• Applicants must submit their applications by 2027-02-09.
• Each selected applicant is eligible to receive up to $700,000.00 in funding.
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 28 013

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: