Opportunity Information: Apply for RFA ES 19 008
The Revolutionizing Innovative, Visionary Environmental health Research (RIVER) program is a National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) grant opportunity designed to support outstanding investigators whose work advances the environmental health sciences. The main idea is to fund most of an investigator's independent research program under one long-term award, rather than having that work split across multiple shorter grants. By doing that, RIVER aims to give investigators more room to think creatively, reduce administrative burden, and allow them to shift direction as new discoveries emerge, with the goal of producing bigger and more meaningful scientific impact over time.
This opportunity uses the R35 mechanism and is specifically labeled for basic experimental studies with humans required. In practice, that means the research is expected to involve human subjects and focus on fundamental scientific understanding rather than immediate practical applications, product development, or clinical intervention outcomes. Projects that fit well include studies that use human participants, samples, or human-focused data to uncover mechanisms by which environmental exposures influence human biology and health. The description highlights mechanistic work on environmental exposure effects and explicitly notes that molecular epidemiological studies can fit within the scope, as long as they are aligned with the basic science intent of understanding underlying phenomena and observable facts.
A defining feature of RIVER is its emphasis on the investigator rather than a narrowly defined project plan. NIEHS is looking for people, at any career stage, who have demonstrated excellence and show strong potential for continued innovation and impact. The award is meant to consolidate the investigator's existing investigator-initiated research portfolio into a single, coherent program. The design supports scientific flexibility, so investigators can pursue promising new directions as the research evolves, without constantly re-competing for multiple separate awards to keep the program running.
In terms of funding and duration, the RIVER award can last up to 8 years, which is longer than many standard NIH research grants and is intended to create stable, sustained support. The typical direct cost level referenced is around $600,000 per year, with the possibility of up to about $750,000 in direct costs depending on the level of current NIEHS funding that is being consolidated into the RIVER award. In other words, the program is structured to roll up and replace multiple streams of NIEHS support, when applicable, into one larger, longer award that covers the bulk of the investigator's research effort.
Eligibility is broad and includes many types of organizations that commonly apply for NIH grants, such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various levels of government entities (state, county, city/township, special districts, and independent school districts). It also includes Native American tribal governments (federally recognized), tribal organizations (other than federally recognized governments), and public housing authorities/Indian housing authorities. The opportunity explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations).
Administratively, the opportunity is a discretionary grant with an environment and health focus (CFDA 93.113). The funding opportunity number is RFA-ES-19-008, and the original closing date listed for the specific notice provided was June 20, 2019, with a creation date of April 4, 2019. Overall, the program is best understood as a long-term, investigator-centered NIEHS investment in basic human-subjects environmental health research, intended to enable ambitious, mechanistic, and potentially field-shaping work by giving investigators both stability and freedom to innovate.Apply for RFA ES 19 008
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2019-04-04.
- Applicants must submit their applications by 2019-06-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (RFA ES 19 008) also looked into and applied for these:
| Funding Opportunity |
|---|
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed) Apply for PAR 19 249 Funding Number: PAR 19 249 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 009 Funding Number: RFA ES 19 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 19 010 Funding Number: RFA ES 19 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 19 004 Funding Number: RFA ES 19 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trial Not Allowed) Apply for RFA ES 19 003 Funding Number: RFA ES 19 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Pregnancy as a Vulnerable Time Period for Women's Health (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 003 Funding Number: RFA ES 20 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $300,000 |
| Limited Competition: Specialized Centers of Excellence on Environmental Health Disparities Research (P50) Apply for RFA MD 20 001 Funding Number: RFA MD 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01 Clinical Trial Not Allowed) Apply for PAR 19 386 Funding Number: PAR 19 386 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R21 Clinical Trial Not Allowed) Apply for PAR 19 385 Funding Number: PAR 19 385 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 005 Funding Number: RFA ES 20 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for RFA ES 20 002 Funding Number: RFA ES 20 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 20 006 Funding Number: RFA ES 20 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 20 009 Funding Number: RFA ES 20 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| U.S. - India Collaborative Environmental Health Research Program (R01 Clinical Trial Optional) Apply for RFA ES 20 010 Funding Number: RFA ES 20 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 012 Funding Number: RFA ES 20 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Collaborative Centers in Children's Environmental Health Research and Translation Centers (P2C Clinical Trial Optional) Apply for RFA ES 20 001 Funding Number: RFA ES 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| RESolution of InflammaTion in EnvirOnmentally Related diseasE (RESTORE) (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 013 Funding Number: RFA ES 20 013 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $350,000 |
| NIEHS SBIR Phase IIB Validation of Sensors for Improved Environmental Exposure Assessment (R44 Clinical Trial Not Allowed) Apply for RFA ES 20 016 Funding Number: RFA ES 20 016 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Pediatric and Reproductive Environmental Health Scholars (PREHS): Strengthening the Pipeline (K12 Clinical Trial Not Allowed) Apply for RFA ES 20 007 Funding Number: RFA ES 20 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $450,000 |
| Utilizing In Vitro Functional Genomics Advances for Gene-Environment (G x E) Discovery and Validation (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 018 Funding Number: RFA ES 20 018 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
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