Opportunity Information: Apply for PAR 20 088
The NIH funding opportunity "Mechanisms of Disparities in Chronic Liver Diseases and Cancer (R01 - Clinical Trial Not Allowed)" (Funding Opportunity Number PAR-20-088) supports research that digs into why chronic liver diseases and liver cancer do not affect all groups in the United States equally. The central aim is to fund multidisciplinary projects that move beyond simply documenting unequal outcomes and instead identify the underlying causes (etiologic factors) and the biological, behavioral, environmental, social, and structural mechanisms that drive those disparities. In practice, this means the program is looking for studies that can explain how and why differences in risk, disease progression, and outcomes arise across populations, with an emphasis on mechanistic understanding rather than purely descriptive epidemiology.
This opportunity uses the NIH R01 mechanism, which is a major research project grant intended for well-developed, hypothesis-driven research programs. The announcement specifies "Clinical Trial Not Allowed," meaning applicants should not propose a study that meets NIH's definition of a clinical trial (for example, prospectively assigning people to an intervention to test health-related outcomes). Research can still involve human participants and patient-oriented work, but it must be observational, mechanistic, or otherwise structured in a way that does not cross into clinical trial territory. The intent is to enable investigators to investigate pathways and causes underlying disparities in chronic liver conditions and cancer, including the interplay of multiple determinants that can vary by geography, race and ethnicity, socioeconomic status, access to care, and other population-level or community-level factors.
The initiative sits within NIH's health mission and falls under the broad activity categories of education and health. It is associated with multiple CFDA numbers (93.307, 93.393, 93.394, 93.395, 93.396, 93.399), reflecting NIH components and related research areas that can be relevant to liver disease and cancer disparities. While the opportunity summary does not list an award ceiling or the expected number of awards, the mechanism and NIH context suggest budgets would be proposed according to R01 norms and justified by the scientific scope of the project.
A wide range of domestic organizations are eligible to apply. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) status); public housing authorities and Indian housing authorities; federally recognized Native American tribal governments; other Native American tribal organizations that are not federally recognized; for-profit organizations other than small businesses; and small businesses. The announcement also explicitly highlights additional eligible applicant types that often play important roles in disparity-focused research, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. This broad eligibility aligns with the program's emphasis on multidisciplinary and community-relevant research capacity across diverse settings.
Foreign eligibility is restricted in a specific way. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. At the same time, "foreign components" are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may include certain international collaborations or project elements when they are scientifically justified and meet NIH policy requirements. In other words, the applicant institution must be U.S.-based, but the work can include approved international components if they are integral to the research questions.
Administrative details included in the source data indicate the opportunity is a discretionary grant program managed by the National Institutes of Health. The opportunity was created on 2020-01-14, and the original closing date listed is 2022-04-01. Overall, the grant is designed for investigators and teams who can bring together expertise across fields to uncover causal pathways and mechanisms behind chronic liver disease and liver cancer disparities in the U.S., with the long-term goal of generating knowledge that can inform more effective prevention, diagnosis, and care strategies tailored to populations experiencing disproportionate burden.Apply for PAR 20 088
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Mechanisms of Disparities in Chronic Liver Diseases and Cancer (R01- Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307, 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2020-01-14.
- Applicants must submit their applications by 2022-04-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Mechanisms of Disparities in Chronic Liver Diseases and Cancer (R01 - Clinical Trial Not Allowed)." The Funding Opportunity Number (FON) is PAR-20-088.
What is the main purpose of PAR-20-088?
The main purpose is to support research that explains why chronic liver diseases and liver cancer do not affect all groups in the United States equally. The focus is on identifying underlying causes (etiologic factors) and the biological, behavioral, environmental, social, and structural mechanisms that drive disparities in risk, disease progression, and outcomes.
What does NIH mean by focusing on "mechanisms" of disparities?
In this program, "mechanisms" refers to the pathways and drivers that create unequal burdens of chronic liver disease and liver cancer across populations. The opportunity emphasizes studies that move beyond documenting differences and instead explain how and why those differences arise, including the interplay of multiple determinants.
Is this opportunity intended for descriptive epidemiology studies?
The emphasis is on mechanistic understanding rather than purely descriptive epidemiology. Projects are expected to go beyond reporting unequal outcomes and instead investigate the underlying reasons those unequal outcomes occur.
What NIH grant mechanism is used for this funding opportunity?
This opportunity uses the NIH R01 mechanism, which is a major research project grant intended for well-developed, hypothesis-driven research programs.
Are clinical trials allowed under this R01?
No. The announcement specifies "Clinical Trial Not Allowed," meaning applicants should not propose a study that meets NIH's definition of a clinical trial (such as prospectively assigning people to an intervention to evaluate health-related outcomes).
Can the proposed research include human participants?
Yes. Research can involve human participants and patient-oriented work, as long as the study is not structured as a clinical trial. The opportunity supports observational, mechanistic, or other non-clinical-trial approaches aligned with NIH policy.
What kinds of factors and drivers of disparities are relevant to this program?
The opportunity highlights investigating biological, behavioral, environmental, social, and structural mechanisms. It also notes that determinants can vary by geography, race and ethnicity, socioeconomic status, access to care, and other population-level or community-level factors.
What disease areas are covered by this opportunity?
The opportunity targets chronic liver diseases and liver cancer, with a specific emphasis on understanding disparities in risk, progression, and outcomes within the United States.
What is the geographic focus of the research?
The program is focused on disparities across populations in the United States. At the same time, certain international elements may be included as foreign components when allowed by NIH policy and when scientifically justified.
Who is eligible to apply as the applicant organization?
A wide range of domestic (U.S.-based) organizations are eligible, including state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); public housing authorities and Indian housing authorities; federally recognized Native American tribal governments; other Native American tribal organizations that are not federally recognized; for-profit organizations other than small businesses; and small businesses.
Does NIH specifically encourage applications from institutions that serve historically underrepresented populations or community organizations?
Yes. The announcement explicitly highlights additional eligible applicant types that often play important roles in disparity-focused research, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant.
Are international collaborations allowed at all?
Yes, in a limited way. "Foreign components" are allowed as defined by the NIH Grants Policy Statement. This means a U.S.-based applicant may include certain international collaborations or project elements if they are scientifically justified and meet NIH policy requirements.
Does the opportunity list a maximum award amount or an expected number of awards?
The provided summary does not list an award ceiling or the expected number of awards. Applicants generally propose budgets consistent with R01 norms and justify the budget based on the scientific scope of the project.
Which federal agency administers this opportunity?
The program is administered by the National Institutes of Health (NIH) and is described as a discretionary grant program.
What are the associated CFDA numbers listed for this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.307, 93.393, 93.394, 93.395, 93.396, and 93.399.
What activity categories are associated with this opportunity?
The opportunity is associated with the broad activity categories of education and health.
When was this funding opportunity created and what is the listed closing date?
The opportunity was created on 2020-01-14, and the original closing date listed is 2022-04-01.
What is NIH trying to achieve in the long term with this program?
The long-term goal is to generate knowledge about causal pathways and mechanisms behind disparities in chronic liver disease and liver cancer so that prevention, diagnosis, and care strategies can ultimately be better informed and more effectively tailored to populations experiencing disproportionate burden.
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| HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) Apply for RFA NS 20 028 Funding Number: RFA NS 20 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HIV/AIDS and the Tumor Niche (U54 Clinical Trial Not Allowed) Apply for RFA CA 20 016 Funding Number: RFA CA 20 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) Apply for RFA CA 20 008 Funding Number: RFA CA 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trial Optional) Apply for PAR 20 092 Funding Number: PAR 20 092 Agency: National Institutes of Health Category: Education, Health Funding Amount: $3,000,000 |
| HEAL Initiative: Pharmacotherapies to Reverse Opioid Overdose Induced Respiratory Depression without Central Opioid Withdrawal (Target Validation and Candidate Therapeutic Development (R61/R33 - Clinical Trial Not Allowed) Apply for RFA HL 20 031 Funding Number: RFA HL 20 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| National Cancer Institute Program Project Applications (P01 Clinical Trial Optional) Apply for PAR 20 077 Funding Number: PAR 20 077 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Training Modules to Enhance the Rigor, Reproducibility and Responsible Conduct of Biomedical Data Science Research (R25 - Clinical Trial Not Allowed) Apply for RFA GM 20 001 Funding Number: RFA GM 20 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Implementing the HIV Service Cascade for Justice-Involved Populations (U01 Clinical Trial Required) Apply for RFA DA 20 028 Funding Number: RFA DA 20 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploring the Roles of Biomolecular Condensates (BMCs) in HIV replication, latency, or pathogenesis in the context of substance use disorders (R21/R33 Clinical Trial Not Allowed) Apply for RFA DA 21 004 Funding Number: RFA DA 21 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Toward Translation of Nanotechnology Cancer Interventions (TTNCI) (R01 Clinical Trial Not Allowed) Apply for PAR 20 116 Funding Number: PAR 20 116 Agency: National Institutes of Health Category: Education, Health Funding Amount: $475,000 |
| National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental or Substance Use Disorders or Alcohol Disorder (U01 Clinical Trial Optional) Apply for PAR 20 118 Funding Number: PAR 20 118 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental or Substance Use Disorders or Alcohol Disorder (U19 Clinical Trial Optional) Apply for PAR 20 119 Funding Number: PAR 20 119 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Strengthening the Impact of Community Health Workers on the HIV Care Continuum in the US (R01 Clinical Trial Optional) Apply for RFA NR 20 002 Funding Number: RFA NR 20 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional) Apply for RFA CA 20 033 Funding Number: RFA CA 20 033 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Core Infrastructure Support for Cancer Epidemiology Cohorts (U01 Clinical Trial Not Allowed) Apply for PAR 20 136 Funding Number: PAR 20 136 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed) Apply for PAR 20 131 Funding Number: PAR 20 131 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R01 Clinical Trial Optional) Apply for RFA CA 20 027 Funding Number: RFA CA 20 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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